We are entering now upon the most important scientific epoch of antiquity. When Aristotle and Theophrastus passed from the scene, Athens ceased to be in any sense the scientific centre of the world. That city still retained its reminiscent glory, and cannot be ignored in the history of culture, but no great scientific leader was ever again to be born or to take up his permanent abode within the confines of Greece proper. With almost cataclysmic suddenness, a new intellectual centre appeared on the south shore of the Mediterranean.